-
1个人简介
-
2代表性论文:
-
3Contact Me
个人简介
王涛,男,博士,研究员,博士生导师。主要研究方向是新型tRNA/RNA修饰的生物学功能和调控机制,细胞衰老(senescence)与生物衰老(ageing)以及癌症等老年疾病之间的关联。2010年在中科院广州生物医药与健康研究院取得博士学位;2012-2015年在北卡莱罗纳大学教堂山分校Norman E. Sharpless教授实验室作为博士后进行衰老相关研究;2015-2017年在耶鲁大学Andrew Xiao实验室研究一种新型的6mA-DNA表观修饰。
代表性论文:
1. Wu, T.P., T. Wang, M.G. Seetin, Y. Lai, S. Zhu, K. Lin, Y. Liu, S.D. Byrum, S.G. Mackintosh, M. Zhong, A. Tackett, G. Wang, L.S. Hon, G. Fang, J.A. Swenberg, and A.Z. Xiao. DNA methylation on N(6)-adenine in mammalian embryonic stem cells. Nature. 2016, 532: 329-333.
2. Chen K, Long Q, Wang T, Zhao D, Zhou Y, Qi J, Wu Y, Li S, Chen C, Zeng X, Yang J, Zhou Z, Qin W, Liu X, Li Y, Huang X, Qin D, Chen J, Pan G, Scholer HR, Xu G, Pei D. Gadd45a is a heterochromatin relaxer that enhances iPS cell generation. EMBO Rep. 2016, 17: 1641-1656.
3. Esteban, M.A.*, Wang, T. *, Qin, B. *, Yang, J., Qin, D., Cai, J., Li, W., Weng, Z., Chen, J., Ni, S., Chen, K., Li, Y., Liu, X., Xu, J., Zhang, S., Li, F., He, W., Labuda, K., Song, Y., Peterbauer, A., Wolbank, S., Redl, H., Zhong, M., Cai, D., Zeng, L., and Pei, D. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell. 2010, 6(1): 71-79. (*Contributed equally).
4. Wang, T., Chen, K., Zeng, X., Yang, J., Wu, Y., Shi, X., Qin, B., Zeng, L., Esteban, M.A., Pan, G., and Pei, D. The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. Cell Stem Cell. 2011, 9(6): 575-587.
5. Chen, J., Liu, H., Liu, J., Qi, J., Wei, B., Yang, J., Liang, H., Chen, Y., Wu, Y., Guo, L., Zhu, J., Zhao, X., Peng, T., Zhang, Y., Chen, S., Li, X., Li, D., Wang, T., and Pei, D. H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet. 2013, 45(1): 34-42."
