范瑞芳 Fan Ruifang

教授/Professor

华南师范大学 生命科学学院

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范瑞芳,女,河南省新乡人,博士,华南师范大学生命科学学院教授,博士研究生导师。任广东省环境诱变剂协会理事, 长期担任Environment International, Environmental Science & Technology, Science of Total Environment, Environmental Research, Scientific Reports, Chemosphere等杂志的审稿人。



在国内外发表中英文论文50余篇,其中30篇被SCI及EI收录,“羧甲基聚合β-CD作为手性剂分离维拉帕米和布比卡因”一文获“第四届全国毛细管电泳及相关微分离分析技术学术报告会组委会”大会论文一等奖,曾获得华南师范大学科研工作优秀奖等荣誉,培养的多名研究生获得“广东省优秀学生”和“国家奖学金”等。

研究兴趣:(1)环境有机污染物生物监测与环境风险评价(2)环境污染物的毒理与健康效应。欢迎具有环境科学、生物技术、环境毒理学背景的学生报考研究生。电子邮件:20001047@m.scnu.edu.cn 和 tgxb@jnu.edu.cn


Researches interested

[1] The biomonitoring of environmental pollutions in urine and blood for populations and the assessment of their environmental risks.

[2] Environmental toxic mechanism and its health effects.


Please contact with :


E-mail:20001047@m.scnu.edu.cn



研究工作经历:

2014.12-今,华南师范大学生命科学学院,教授。

2010.09-2012.03,获国家留学基金委资助,赴美国加州公共卫生局(California Department of Public Health)访学一年半。

2006.12-2014.12,华南师范大学生命科学学院,副教授。

2001.12-2006.11,华南师范大学生命科学学院,助理研究员。

2000.03-2001.11,华南师范大学生命科学学院,实习研究员。




教育经历:

2004.03-2007.06,中科院广州地球化学研究所,博士。

1997.09-2000.02,北京理工大学,硕士。

1991.09-1995.06,河南师范大学,本科。




近5年主持/参与的国家、省部级基金项目有:

[1] 国家自然科学基金(21777048),2018.01-2021.1264万元,主持,在研。

[2] 国家自然科学基金重点项目(41731279),2018.01-2022.12323万元,第一参与人/子课题负责人,在研。

[3] 广州市科技计划项目(201510010107),20万,2015.06-2018.06,主持,结题。

[4] 国家自然科学基金(21477041),87万元,2015.01-2018.12,主持,结题。

[5] 广东省自然科学基金(S2013010013183),5万元,2013.10-2015.10,主持,结题。

[6] 教育部留学回国人员科研启动基金(教外司留[2013]693号),3万元,2013.07-2015.07,主持,结题。

[7] 教育部博士点基金(20124407120005),4万元,2012.12-2015.12,主持,结题。

[8] 环境保护部全国重点地区环境与健康专项调查基金子课题(21111011101EHH(2011)-206),8万元,2011.07-2013.02,主持,结题。


Research fundings:

【1】 Effects of low-dose and perinatal exposure to bisphenol A on brain cell of offspring mice as well as its relationships with altered behavior of children, supported by National Natural Science Foundation of China (grant No. 21777048), ¥640,000, 2017.01-2020.12.

【2】Effects of long-term and low-dose exposure to bisphenol A on brain cell and behavior in several generations of mice during perinatal period, supported by the Guangzhou Key Laboratory of Environmental Exposure and Health (grant No. GZKLEEH201607), ¥50,000, 2016.06-2018.06.

【3】Relationships between polycyclic aromatic hydrocarbon exposure levels and DNA damage, lung function of children, supported by National Natural Science Foundation of China (grant No.21477041), ¥870,000, 2015.01-2018.12.

【4】Effects of Long-term exposure to bisphenol A on brain cell and their relationships with the change of children behavior, supported by Science and Technology Program of Guangzhou, China (grant No.201510010107), ¥200,000, 2015.01-2017.12.

【5】Relationships between the urinary bisphenol A exposure for kindergarten children in Guangzhou, the oxidative DNA damage and the dust concentration, supported by Natural Science Foundation of Guangdong, China (grant No. S2013010013183), ¥50,000, 2013.10-2015.10.

【6】Primary study of aromatic carcinogenic compounds in PM2.5 air and its effects on children in Guangzhou, Supported by Scientific Research Foundation for Returned Scholars, Ministry of Education of China (grant No. [2013] 693), ¥30,000, 2013-2015.

【7】 Primary study of aromatic carcinogenic compounds in PM2.5 air and its effects on children in Guangzhou, supported by Research Fund for the Doctoral Program of Higher Education of China (grant No. 20124407120005), ¥40,000, 2013.0-2015.05.

【8】 QA/QC system of the quantitation of hydroxyl PAH in urine, supported by Ministry of Environmental Protection, sub-funding of environmental health special survey of the key area of China (grant No. 21111011101EHH(2011)-206), ¥80,000, 2011.10-213.02.

【9】 Children’s exposure level to PAHs in Guangzhou and their relationships with DNA damage, supported by Open Project of Chinese state key laboratory of organic chemistry (grant No OGL-200706). ¥20,000, 2008.01-2009.12.


近年以通讯以及第一作者发表的代表性文章(Publications in the past five years):

(1) Hongxuan Kuang, Yanyan Dai, Yonghong Li, Caihui Cha, Wenhui Jiang, Qihua Pang, Haibin Zhang, Ruifang Fan*. The association among blood BPDE-DNA adducts, serum interleukin-8 (IL-8) and overall DNA damage for children with pulmonary disease. International Journal of Environmental Health Research, 2019, 1-12.

(2) Hongxuan Kuang, Yonghong Li, Wenhui Jiang, Peiqiong Wu, Jianhua Tan, Haibin Zhang, Qihua Pang, Ruifang Fan*. Simultaneous determination of 31 urinary VOC metabolites8-hydroxy-2′-deoxyguanosine and trans-3′-hydroxy-cotinine by UPLC-MS/MS: The effect of isotoped internal standards on elimination of matrix effect, Analytical and Bioanalytical Chemistry, 2019, 411:7841-7855.

(3) Haibing Zhang, Kuanghong Xuan, Yifan Luo, Shuhua Liu, Lingxue Meng, Qihua Pang, Ruifang Fan*. Low-dose bisphenol A exposure impairs learning and memory ability with alterations of neuromorphology and neurotransmitters in rats, Science of the Total Environment, 2019, 697:134036. SCI2018=5.589)

(4)Qihua Pang#, Yanru Li#, Lingxue Meng, Guanyong Li, Zhiwei uo, Ruifang Fan*. Neurotoxicity of BPA, BPS and BPB for the hippocampal cell line (HT-22): an implication for the replace of BPA in plasticsChemosphere, 2019, 226:545-552. (SCI2018=5.108)

(5) 邝洪轩,张海彬,谭建华,雒亦凡,刘舒华,庞启华,李楚华,范瑞芳*. 维生素C抗氧化-同位素内标稀释-超高效液相色谱串联质谱法同时测定新生期大鼠海马体神经递质的含量,色谱,2019374):404-411

(6) Laiguo Chen, Guocheng Hu, Ruifang Fan*, Yanshan Lv, Yanyan Dai, Zhencheng Xu*. Association of PAHs and BT exposure with lung function and respiratory symptoms among non-occupational population near the coal-chemical industry in Northern China. Environment International, 2018, 120:480-488. SCI2017=7.297, 1)

(7)Yanru Li, Haibin Zhang, Hongxuan Kuang, Ruifang Fan*, Caihui Cha*, Guanyong Li, Zhiwei Luo, Qihua Pang. Relationship between Bisphenol A exposure and Attention-deficit/ hyperactivity disorder: A case-control study for primary school children in Guangzhou, China. Environmental Pollution, 2018, 235:141-149. (SCI=5.099, 2区)

(8) Yuanxiu Zhou, Zhouyu Wang, Minghan Xia, Siyi Zhuang, Xiaobing Gong*, Jianwen Pan, Chuhua Li, Ruifang Fan*, Qihuang Pang, Shaoyou Lu. Neurotoxicity of low bisphenol A (BPA) exposure for young male mice: An implication for children expoed to environmental level of BPA, Environmental Pollution, 2017,229:40-48. (SCI, IF2016=5.099)

(9) Yanshan Lv, Shaoyou Lu, Yanyan Dai, Caiyan Rui, Yongjun Wang, Yanru Li, Yuanxiu Zhou, Qihua Pang, Ruifang Fan*. Higher dermal exposure of cashiers to BPA and its association with DNA oxidative damage, Environment International, 2017, 98:69-74. (SCI, IF2016=7.088).

(10) Yanshan Lv, Caiyan Rui, Yanyan Dai, Qihua Pang, Yanru Li, Ruifang Fan*, Shaoyou Lu*. Children exposure to BPA through dust and the association of urinary BPA, triclosan with oxidative stress in Guangzhou, China. Environmental Science: processes & impact, 2016, 18:1492-1499. (SCI, IF2016=2.592)

(11) Shaoyou Lu, Lu Ren, Jianzhang Fang, Jiajia Ji, Guihua Liu, Jianqing Zhang, Huimin Zhang, Ruorong Luo, Kai Lin, Ruifang Fan*. Trace elements can increase urinary 8-hydroxy-2’-deoxyguanosine level: a case study of college students in Guangzhou, China. Environmental Science and Pollution Research, 2016, 23:8484-8491. (SCI, IF2016=2.741)

(12) Junnan Li, Shaoyou Lu, Guihua Liu, Yuanxiu Zhou, Yan Shan Lv, Jianwen She, Ruifang Fan*. Co-exposure to polycyclic aromatic hydrocarbons, benzene and toluene and their dose-effects on oxidative stress damage in kindergarten-aged children in Guangzhou, China. Science of the Total Environment, 2015, 524-525:74-80. (SCI, IF=3.976)

(13) Ruifang Fan*, Biyan Zeng , Xiaosu Liu, Chao Chen, Qinwei Zhuang, Yongjun Wang, Mingli Hu, Yanshan Lv, Junnan Li, Yuanxiu Zhou, Zhi Yuan (William) Lin. Bisphenol-A levels from different paper products and their human exposure estimations in Guangzhou, China. Environmental Science: Process & Impact, 2015, 17: 667-673. (SCI, IF=2.401)

(14) Ruifang Fan*, Dongli Wang, Jianwen She. Method development for the simultaneous analysis of trans, trans-muconic acid, 1, 2-dihydroxybenzene, S-phenylmercapturic acid and S-benzylmercapturic acid in human urine by liquid chromatography/tandem mass spectrometery. Analytical Methods, 2015, 7: 573-580. (SCI, IF=1.915)

(15) Junnan Li, Ruifang Fan*, Shaoyou Lu*, Yuanxiu Zhou, Yanshan Lv. Exposure to Polycyclic Aromatic Hydrocarbon could cause their oxidative DNA Damage: A Case Study for College Students in Guangzhou, China. Environmental Science and Pollution Research, 2015, 22: 1770-1777. (SCI, IF.=2.76)

(16) Ruifang Fan, Junnan Li, Laiguo Chen*, Zhencheng Xu*, Yuanyuan Zhu, Jihua Li. Biomass fuels and coke plants are important sources of human exposure to polycyclic aromatic hydrocarbons, benzene and toluene, Environmental Research, 2014, 135:1-8. (SCI, IF.=4.373)

(17) Ruifang Fan*, Dongli Wang, Chuanwei Mao, Jianwen She et al. Preliminary study of children’s exposure to PAHs and its association with 8-hydroxy-2’-deoxyguanasine in Guangzhou, China. Environment International, 2012, 42:53-58. (SCI, IF. =6.248 )

(18) Ruifang Fan, Dongli Wang, Robert Ramage, Jianwen She*. Fast and simultaneous determination of urinary 8-hydroxy-2'-deoxyguanosine and ten monohydroxylated polycyclic aromatic hydrocarbons by liquid chromatography/tandem mass spectrometery. Chemical Research in Toxicology, 2012, 25(2)491-499. (SCI, IF. = 3.667.)

(19) Ruifang Fan, Robert Ramage, Dongli Wang, Junqiang Zhou, Jianwen She*. Determination of ten monohydroxylated polycyclic aromatic hydrocarbons by liquid-liquid extraction and liquid chromatography/tandem mass spectrometry, Talanta, 2012, 93: 383-395. (SCI, IF. = 3.498.)


国家发明专利 (Patents):
范瑞芳,液相色谱串联质谱分析尿液中苯和甲苯四种代谢产物的方法,授权专利号:ZL-201310067770.3,授权日期:2014年4月2日。
























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