Education & Positions

Yunnan University, B.S., 2013

University of Chinese Academy of Sciences, M.D., 2016

Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, office worker, 2017

Shandong University, Ph.D., 2022

Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Associate Professor, 2022-

Research Interests

Natural product is a crucial source of novel drug development. However, a key problem hindering natural products study is the unknown mechanism of action. Therefore, how to identify the direct target for these bioactive natural products is a pivotal scientific issue. Our group is mainly engaged in discovery of active components from natural medicines and the molecular mechanism of blood development，including three aspects: 1) identify active ingredients of traditional Chinese medicines and the direct target for these bioactive natural products; 2) Screening of active compounds based on targeted proteins, such PPM1B; 3) erythroid cell development, hematopoietic stem cell self-renewal and molecular regulation. Collectively, our research can not only reveal the detailed pharmacological mechanism for the bioactive natural products, and also provide the novel therapeutic targets for new drug development in clinical. 

Grants and fundings

National Natural Science Foundation of China (81874294)

Shandong Natural Science Fund (21510005202107)

Multidisciplinary Research and Innovation Team of Young Scholars (2020QNQT007)

Rongxiang Regenerative Medicine Foundation of Shandong University (2019SDRX-04)

Innovative Research Team in University of Ministry of Education of China (IRT_17R68)

Investigator

Recent Publications

1. Zhiyuan Lu, Lixia Huang, Yanxia Li, et al. Fine-tuning of cholesterol homeostasis controls erythroid differentiation. Advanced Science. 2021,2102669:1-17. (Q1, IF: 17.52)

2. Zhiyuan Lu, Peng Xiao, Yuan Zhou, et al. Identification of HN252 as a potent inhibitor of protein phosphatase PPM1B. Journal of Cellular and Molecular Medicine. 2020, 00: 1-9. (Q2, IF: 5.32)

3. Zhiyuan Lu, Guangsen Xu, Yanxia Li, et al. Discovery of N-arylcinnamamides as Novel Erythroblast Enucleation Inducers. Bioorganic Chemistry. 2022,128,106105. (Q2, IF: 5.30)

4. Shuai Wang#, Zhiyuan Lu#, Yuxin Wang, et al. Metalloproteins and apolipoprotein C: candidate plasma biomarkers of T2DM screened by comparative proteomics and lipidomics in ZDF rats. Nutrition & Metabolism. 2020, 17: 66. (Q3, IF: 4.72)

5. Yuanzhen Zhang, Yan Xu, Shujing Zhang, Zhiyuan Lu, Yuan Li, Baobing Zhao. The regulation roles of Ca2+ in erythropoiesis: What have we learned? Experimental Hematology. 2022, 106:19-30. (Q3, IF: 3.25)

Contact Information

Website: www.scholat.com/Luzhiyuan

Email: lzy520406@163.com; luzhiyuan@sdlmu.edu.cn

Address: No.6699 Qingdao Road, Jinan 250117, Shandong Province, China