Name:         Chonghua Ren

ORCID:        0000-0001-8221-0957

Address:      School of Life Sciences

                      South China Normal University

                      No.55, West of Zhongshan Avenue, Tianhe Distric, Guangzhou 510631, China

Email:          renchonghua111(at)m.scnu.edu.cn

Post-Doctoral      2017-2019   South China Normal University, China 

Ph.D.                     2011-2014   Northwest A&F University, China 

                               2014-2016   University of California, Davis, USA    

B.S.                        2007-2011   Northwest A&F University, China

2021-present  Professor (Investigator), South China Normal University, China.

2019-2020     Associate Professor (Tenured), South China Normal University, China.

2022-present   International Society for Regenerative Biology

2021-present   Chinese Society for Cell Biology

2019-present  The Entomological Society of China

2017-present  The Entomological Society of Guangdong Province

(1) Transcriptional regulation of insect limb regeneration

Regeneration of tissues and organs is one of the most fascinating phenomena in biological research, and has also been listed as one of the 125 cutting-edge scientific problems in the world by the journal Science. Limb regeneration is a common phenomenon in insects and most of them have strong regenerative ability. Studying the transcriptional regulation mechanism of insect limb regeneration can provide reference for the process of vertebrate regenerative biology.

(2) Epigenetic function in insect development and limb regeneration

Tissue development and regeneration involve many biological processes such as gene Expression and cell fate determination, and epigenetic (histone and DNA modifications) plays an important role in tissue regeneration as a key factor regulating gene Expression. We aim to explore the roles of genetic/epigenetic in development and regeneration.

(3) Insect gene editing and functional studies.

Through the establishment of insect CRISPR/Cas9 gene editing technology platform, the function of key genes in tissue development and regeneration can be studied under the condition of gene knockout and knockin.

（1） Zheng Zhao†, Liang Li †, Ruichen Zeng, Liangguan Lin, Dongwei Yuan, Yejie Wen, Na Li, Yingying Cui, Shiming Zhu, Zhi-Min Zhang, Sheng Li*, and Chonghua Ren*. 5mC modification orchestrates choriogenesis and fertilization by preventing prolonged ftz-f1 Expression. Nature Communications. 2023 Dec 12;14(1):8234 (IF=16.6)

（2） Chonghua Ren# *, Yejie Wen#, Shaojuan Zheng#, Zheng Zhao#, Ethan Yihao Li, Chenjing Zhao, Mingtao Liao, Liang Li, Xiaoshuai Zhang, Suning Liu, Dongwei Yuan, Wei Wang, Jifeng Fei, Sheng Li*. Two transcriptional cascades orchestrate cockroach leg regeneration. Cell Reports. 2024 （in press）

（3）Xiaoshuai Zhang# *, Lin Wei#, Wei Zhang, Feixue Zhang, Lin Li, Liang Li, Yejie Wen, Jiahui Zhang, Suning Liu, Dongwei Yuan, Yanmei Liu, Chonghua Ren*, Sheng Li*. Science Advances. 2024 10:adk8331

（4） Chonghua Ren#, Nan Chen#, Sheng Li*. Harnessing “Little Mighty” cockroaches：Pest management and beneficial utilization. The Innovation. 2023. Nov 13; 4(6): 100531. (IF=33.1)

（5） Chonghua Ren#, Kun Xu#, David Jay Segal, Zhiying Zhang. Strategies for the enrichment and selection of genetically  modified cells. Trends in Biotechnology. 37(1) 2019 pp. 58-73 (IF=21.942)

（6） Jiru Zhong#, Andi Jing#, Shaojuan Zheng, Sheng Li, Xiaoshuai Zhang* and Chonghua Ren*. Physiological and molecular mechanisms of insect appendage regeneration. Cell Regeneration. 2023 12:9

（7） Sheng  Li#,  Shiming Zhu#, Qiangqiang Jia#, Dongwei Yuan#, Chonghua  Ren#, Kang Li, Suning Liu, Yingying Cui, Haigang  Zhao, Yanghui Cao, Gangqi Fang, Daqi Li, Xiaoming Zhao, Jianzhen Zhang, Qiaoyun  Yue, Yongliang Fan, Xiao-Qiang Yu, Qili Feng, and Shuai Zhan. The genomic and functional landscapes of developmental plasticity in the American cockroach. Nature Communications. 2018. DOI: 10.1038/s41467-018-03281-1  (共同第一作者) (JCR: Q1, IF=16.6)

（8） Chonghua Ren, Alexa Adams, Benjamin Pyles, Barbara J. Bailus, Henriette O’Geen, David J. Segal. In-vivo applications of cell-penetrating zinc finger transcription factors. In: Liu J. (eds) Zinc Finger Proteins. Methods in Molecular Biology, vol 1867. Humana Press, New York, NY ISBN:978-1-4939-8799-3

（9）  Henriette O’Geen#, Chonghua Ren#, Charles M. Nicolet, Andrew A. Perez, Julian Halmai, Victoria M. Le, Joel P. Mackay, Peggy J. Farnham and David J. Segal.  dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression. Nucleic Acids Research. 2017. DOI: 10.1093/nar/gkx578 (共同第一作者) (JCR: Q1, IF=19.16)

（10） Chonghua Ren#, Kun Xu#, Zhongtian Liu, Juncen Shen, Furong Han, Zhilong Chen, Zhiying Zhang. Dual-reporter surrogate systems for efficient enrichment of genetically modified cells. Cellular and Molecular Life Sciences. 2015.  72(14), p. 2773-4 (JCR: Q1, IF=9.234)

（11） Kun Xu#, Chonghua Ren#, Zhongtian Liu, Tao Zhang, Tingting Zhang, Duo Li, Ling Wang, Qiang Yan, Lijun Guo, Juncen Shen, Zhiying Zhang. Efficient genome engineering in eukaryotes using Cas9 from Streptococcus thermophilus. Cellular and Molecular Life Sciences. 72 (2) (2014), pp. 383–399 http://dx.doi.org/10.1007/s00018-014-1679-z (共同第一作者) (IF=9.234, 2014 Global Medical Discovery 'Key scientific article')

（12） Zheng Zhao#, Liang Li#, Min Cheng#, Andi Jing, Suning Liu, Shiming Zhu, Erxia Du, Sheng Li, Yunxia Luan*, Chonghua Ren*. Grainy head signaling regulates epithelium development and ecdysis in Blattella germanica. Insect Science. 2021 Apr;28(2):485-494 (IF=4.0)

Chonghua Ren, Kun Xu, Zhongtian Liu, Zhiying Zhang. A surrogate reporter with dual-reporter genes for efficient enrichment of genetic modified cells. (Abstract) The 34th International Society for Animal Genetics Conference. 2014, China.

Lijun Guo, Kun Xu, Chonghua Ren, Zhiying Zhang. Cloning and assembling the Streptococcus thermophiles CRISPR3/Cas locus for prokaryotic genome engineering. (Abstract) The 34th International Society for Animal Genetics Conference. 2014, China.

Chonghua Ren, Benjamin R. Pyles, Henriette O’ Geen, Michael C. Pride, Nathalie Buscher, Nycole A. Copping, Jill L. Silverman And David J. Segal. Generation and preliminary characterization of artificial transcription factors (ATFs) for the regulation of Shank3 in a preclinical model of Phelan McDermid Syndrome and Autism. (Abstract) Neuroscience 2016, USA

Henriette O’Geen, Chonghua Ren, Julian Halmai, Victoria Lee, Charles M. Nicolet, Joel P. Mackay, Peggy J. Farnham, and David J. Segal. dCas9 Epigenome Editing Suggests Histone Methylation Does Not Always Precede Target Gene Repression. (Abstract) American Society for Gene and Cell therapy. 2017, USA

National Scholarship for Graduate students, Chinese Ministry of Education，2015

National Encouragement Scholarship (1/30), Chinese Ministry of Education, 2007-2008, 2008-2009, 2009-2010

“Qingsong” Scholarship, 2009-2010

Email：renchonghua111(at)m.scnu.edu.cn